Town host Cheltenham Town at Blundell Park on Saturday afternoon (3pm) as they look to put their recent run of form behind them.
The Mariners are now without a win in 10 games, so will be hoping that they can turn that around in front of their fans against a side that were promoted along with Town from the National League last campaign.
Cheltenham are in a similar position to Town in the table, so it should be a tight affair and one that boss Russell Slade will be aiming to earn three points from.
New loanees could debut and Dembele in contention
Town could hand debuts to new loan signings Simeon Jackson and Villa defender Easah Suliman after the pair signed on deadline day.
Those signings have come just in time with Mitch Rose and Karleigh Osborne both set to miss the game after they were both sent off in the loss to Yeovil Town on Tuesday night. Ben Davies is also a doubt after picking up an injury in the same game.
Another positive is that Siriki Dembele could also come into contention afer having a scan on his back injury that revealed no serious issues.
Cheltenham could also hand debuts to new loanees themselves in defender Joe Rodon and midfielder Jake Andrews themselves, whilst striker Sanmi Odelusi return to the fold after a month out.
Robins looking to consolidate
Cheltenham will be looking to continue to push up the table after a better season than last campaign so far under Gary Johnson.
The Robins still have many of the players that saw them promoted to the EFL two seasons ago, so Town will face plenty of familiar faces in the form of former midfield loanee Harry Pell and target man striker Danny Wright in particular.
Striker Mohamad Eisa is one player that the Mariners aren't so familiar with but will have to watch out for after his 14 goals so far this campaign
Gary Johnson's side have had a difficult month and have only won one of their last seven games themselves, so they will be looking to bounce back at the weekend.
Town looking to do the double
The Mariners will be looking to do the double over the Robins after one of their best performances of the season in the 3-2 victory over Cheltenham back in October.
Two goals from Siriki Dembele and a Danny Collins header gave the Mariners a 3-1 lead by half time in that game so Russell Slade's men will be hoping to take their chances once again.
Russell Slade: "Any suspension, if somebody is playing, is going to have an impact, whether you like it or not.
“You have to rely on the group that you have got, and trust the players that come in and take a shirt.”
"If it means changing the shape we will have to do that."
Gary Johnson: “We have to make sure we don’t just have to turn up. You have to play well at Grimsby and supporters will be on their side while they are in it and if we can get an early goal or go a goal up, it could change.
“It’s a great opportunity, of course. They’ve brought in a couple of new players, including Easah Suliman, who we know well, and the boy Simeon Jackson.
“I went with Aaron Downes to watch Yeovil Town play Grimsby and unfortunately after six minutes they were down to ten-men, their shape changes and they get new players.”